Becky Davis

Becky Davis

@beckydavis

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2026-01-26 07:40:28 · Translate ·

Recent Progress of PROTACs Targeting Non-enzymatic Functional Proteins

Introduction to Enzyme Function and PROTAC Classical enzymes usually consist of enzyme domains and non-enzyme domains. The functional domain of an enzyme is the region with a specific spatial structure where the enzyme performs its catalytic function. Specifically, the enzyme active site contains a binding region and a catalytic region, which participate in the binding of substrates and...

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2026-01-26 07:39:20 · Translate ·

What is Polyethylene Glycol Used For?

Polyethylene glycol (PEG) is an important class of polymer compounds, which is widely used in medicine, cosmetics, food, industry and other fields. The basic chemical structure of PEG is repeated -(CH2CH2O)- units, and the molecular weight ranges from hundreds to tens of thousands. PEGs of different molecular weights have significant differences in physical and chemical properties, which...

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2026-01-26 07:38:27 · Translate ·

How to Manufacture Antimicrobial Peptides Efficiently

Manufacturing in large scale once meant accepting astronomical prices and cost-plus contracts. Generics, and market growth, have proven that the two are mutually exclusive. Process designers who link cost directly to the choice of carbon source and host strain are no longer choosing the two as if they were cost centers to be optimized separately. Instead, carbon source, host genome and...

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2026-01-26 07:33:35 · Translate ·

What is the biotin labeled RNA?

Biotin-labeled RNA denotes RNA molecules that have undergone chemical modification via the inclusion of biotin, a water-soluble vitamin often known as vitamin B7 or H. This diminutive, yet very adaptable, molecule facilitates the effective detection, separation, and manipulation of RNA molecules owing to the strong interaction between biotin and streptavidin (or avidin). Biotin labeling in...

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2025-12-31 06:34:29 · Translate ·

Comprehensive Guide to Linker-Payload Design Strategies in ADC Project

Linker-payload design is a critical aspect of antibody-drug conjugate (ADC) development, directly determining the stability, targeting ability, and therapeutic efficacy of the drug in vivo. With the advancement of targeted therapies and precise drug delivery technologies, scientists are increasingly focusing on the chemical compatibility, spatial configuration, and pharmacokinetic...

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2025-12-31 06:32:05 · Translate ·

What is CRISPR-Cas9 in Gene Editing

The CRISPR-Cas system is a natural immune system in prokaryotes. Some bacteria, upon being invaded by viruses, can store a small segment of the viral genes in a region within their DNA known as CRISPR. Upon encountering the virus again, the bacteria can recognize the virus based on the stored segment, enabling them to cleave the viral DNA, rendering it ineffective. The invading...

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2025-12-31 06:31:07 · Translate ·

Strategies for Incorporating Unnatural Amino Acids into Proteins

Incorporating unnatural amino acids into proteins is a core strategy in modern protein engineering and chemical biology research. By introducing unnatural amino acids (UAAs) with specialized functions into protein molecules, researchers can achieve precise control over protein structure, activity, and function. This technology not only expands the chemical diversity of proteins but also opens...

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