Cailynn Johnson

Cailynn Johnson

@cailynn

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Cailynn Johnson @cailynn adicionou um novo artigo in Health
2025-11-26 09:01:44 · Traduzir ·

How Organoids Are Revolutionizing Neuroscience

The human brain is a marvel of complexity, but studying it has always been a challenge. Traditional models—animal testing, 2D cell cultures, even postmortem tissue—often fall short in replicating the dynamic environment of a living brain. Enter brain organoids: tiny, lab-grown structures that mimic the architecture and function of human brain regions. These 3D models are opening new...

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Cailynn Johnson @cailynn adicionou um novo artigo in Health
2025-11-26 09:01:10 · Traduzir ·

Exploring CAR-T Therapy for Hemophilia and Transplant Rejection

Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized the treatment landscape for hematologic malignancies, offering targeted, durable responses where conventional therapies often fall short. But what if this cellular precision could be redirected beyond cancer—to chronic, non-oncological diseases like hemophilia or transplant rejection? Recent advances suggest that...

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Cailynn Johnson @cailynn adicionou um novo artigo in Health
2025-11-26 09:00:39 · Traduzir ·

The Expanding Role of Oligonucleotide Modifications and Aptamer Conjugates in Gene Therapy

Gene therapy has entered a new era—one defined not just by bold concepts, but by molecular finesse. At the heart of this transformation are oligonucleotides: short strands of nucleic acids that can silence, edit, or regulate genes with remarkable specificity. But their journey from concept to clinic is anything but straightforward. The Challenge: Biological Barriers Unmodified...

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Cailynn Johnson @cailynn adicionou um novo artigo in Health
2025-11-26 09:00:03 · Traduzir ·

Exploring the Fusion of Organ-on-a-Chip and Droplet Platforms

Traditional drug screening and disease modeling—long reliant on 2D cell cultures and animal models—are increasingly criticized for their limited predictive power and inefficiency. As the demand for personalized medicine and high-throughput testing grows, researchers face a critical question: How can we build more realistic, scalable, and responsive in vitro systems? One...

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Cailynn Johnson @cailynn adicionou um novo artigo in Health
2025-11-26 08:59:26 · Traduzir ·

Understanding Macrophage Polarization

In the past decade, macrophages have evolved from being seen as simple immune sentinels to multifaceted regulators of inflammation, tissue remodeling, and tumor progression. The classical M1/M2 dichotomy—pro-inflammatory versus anti-inflammatory—has served as a useful framework, but it’s increasingly clear that macrophage states exist on a continuum, shaped by...

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Cailynn Johnson @cailynn adicionou um novo artigo in Health
2025-11-26 08:58:46 · Traduzir ·

Tackling Glycan Complexity with Advanced Antibody Tools

Anti-glycan antibodies represent one of the most promising yet challenging frontiers in biotechnology. Their ability to decode the "sugar language" of cells opens doors to diagnostics, therapeutics, and vaccine design—but the complexity of glycans demands advanced technologies and collaborative innovation. The Challenge of Glycan Complexity Unlike DNA or proteins, glycans are...

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Cailynn Johnson @cailynn adicionou um novo artigo in Health
2025-11-26 08:58:08 · Traduzir ·

Glycoproteins: The Hidden Language of Disease

"Glycosylation is not decoration—it's communication," notes a recent review in Nature Reviews Drug Discovery (Vol. 21, 2022). That simple statement captures why glycoproteins have become one of the most compelling frontiers in biomedical research. These sugar‑coated proteins are not passive ornaments; they are active messengers, shaping how cells talk, how the immune...

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Cailynn Johnson @cailynn adicionou um novo artigo in Health
2025-11-26 08:56:39 · Traduzir ·

Lipid-Based Drug Delivery: A Game Changer in Antiviral Research?

In the shadow of every viral outbreak lies a deeper challenge: how do we deliver therapeutics precisely, safely, and effectively to the cells that need them most? While vaccine development and antiviral discovery often dominate headlines, the unsung hero of modern virology may well be lipid-based drug delivery systems. These microscopic carriers—liposomes, lipid nanoparticles (LNPs), and...

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