Thomas Schmitt

Thomas Schmitt

@thomasm

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Thomas Schmitt @thomasm toegevoegd een audio in Health
2026-06-29 09:15:05 · Translate ·

High-Performance Humanized Control Antibodies to Advance Infectious Disease Diagnostics

The main categories of infectious diseases include: 1) viral infections (e.g. SARS-CoV-2, influenza, HIV, dengue fever and hepatitis B and C); 2) bacterial infections (e.g. tuberculosis, salmonellosis and Lyme disease); 3) parasitic infections (e.g. malaria and leishmaniasis); 4) fungal infections (e.g. candidiasis and histoplasmosis); 5) prion diseases (e.g. Creutzfeldt-Jakob disease, fatal...

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Thomas Schmitt @thomasm toegevoegd een audio in Health
2026-06-24 07:07:33 · Translate ·

Advanced MERS-CoV Animal Models to Accelerate Coronavirus Vaccine and Drug Development

MERS-CoV is an emerging zoonotic virus that is considered to be one of the major public health threats. Since 2012, there have been consistent monthly cases of MERS-CoV causing severe respiratory illness, resulting in the death of approximately 35% of confirmed patients. It is believed that the virus is transmitted from camels in Middle Eastern countries through contact between humans and...

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Thomas Schmitt @thomasm toegevoegd een audio in Health
2026-06-24 03:41:35 · Translate ·

Rainbow Trout Hepatocytes to Advance Toxicology and Metabolism Research

Metabolic stability is a key factor to consider in the early stages of drug discovery. Even if a compound possesses promising pharmacological properties, it will never become a drug if it has poor metabolic stability. For instance, if a drug is rapidly metabolized in vivo, exposure levels may be insufficient, which could lead to the formation of toxic, inactive or active metabolites....

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Thomas Schmitt @thomasm toegevoegd een audio in Health
2026-01-09 08:03:44 · Translate ·

New ELISA Kit for the Reliable Detection of JCV IgG Antibodies

Since the discovery of JC polyomavirus, the understanding of this virus among the research community has grown considerably. However, JCV remains enigmatic due to the mystery surrounding its dual survival mode, as it is the causative agent of progressive multifocal leukoencephalopathy (PML), which is a fatal central nervous system disorder. In most individuals, JCV replicates benignly within...

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Thomas Schmitt @thomasm toegevoegd een audio in Health
2026-01-09 08:02:19 · Translate ·

Advanced Hepatitis Virus Animal Models to Accelerate HBV Drug and Vaccine Development

The hepatitis B virus is a potent pathogen capable of inducing chronic infections that lead to multiple liver diseases, including acute and chronic hepatitis, cirrhosis, and particularly primary hepatocellular carcinoma, which poses a significant health threat in the Asia-Pacific region. Although currently approved antiviral therapies (including pegylated interferon [IFN] and nucleoside...

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Thomas Schmitt @thomasm toegevoegd een audio in Health
2026-01-09 08:00:34 · Translate ·

New Line of Subcellular Fractions for In Vitro Metabolism Studies

In vitro drug metabolism research has the advantage over in vivo studies of minimizing physiological interference, thereby enabling direct assessment of the selective metabolic action of enzymes on substrates. Due to their relatively simple preparation and stability, subcellular models are widely used in in vitro drug metabolism studies. Commonly used subcellular fractions include microsomes,...

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Thomas Schmitt @thomasm updated the profile picture
2026-01-09 07:58:30 · Translate ·

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